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Association between cigarette smoking,APCmutations and the risk of developing sporadic colorectal adenomas and carcinomas

✍ Scribed by Mona Sæbø; Camilla F Skjelbred; Rebecca Breistein; Inger Marie B Lothe; Per Chr Hagen; Gunter Bock; Inger-Lise Hansteen; Elin H Kure


Book ID
115010963
Publisher
BioMed Central
Year
2006
Tongue
English
Weight
297 KB
Volume
6
Category
Article
ISSN
1471-2407

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## Abstract Cigarette smoke contains polycyclic hydrocarbons and arylamines that may both be activated by sulfotransferase, encoded by __SULT1A1__. A genetic polymorphism leads to an Arg213His substitution, thereby decreasing enzyme activity and stability and might thus modify the association betwe