Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese
โ Scribed by Yi-Mei J Lin; Fabian Davamani; Wei-Chih Yang; Te-Jen Lai; H Sunny Sun
- Book ID
- 119909337
- Publisher
- BioMed Central
- Year
- 2008
- Tongue
- English
- Weight
- 201 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1744-9081
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Monoamine oxidases catalyse the oxidative degradation of biogenic amines including neurotransmitters such as noradrenaline, dopamine, and 5-hydroxytryptamine (5-HT). Three groups have reported positive associations of the monoamine oxidase A (MAOA) gene with bipolar affective disorder although other
~ W e have tested the hypothesis that DNA markers in the MAOA gene show allelic association with bipolar affective disorder. Eighty-four unrelated Caucasian patients with DSM 111-R bipolar disorder and 84 Caucasian controls were typed for three markers in MAOA a dinucleotide repeat in intron 2, a VN