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Assessment of the dependence potential of the putative 5-HT1A agonist anxiolytic S-20499 in rats

✍ Scribed by Goudie, A.J.; Leathley, M.J.; Cowgill, J.

Book ID
123331201
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
132 KB
Volume
3
Category
Article
ISSN
0924-977X

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Previous studies have shown that (\*) S 20244 (8-(4-[N-(5-methoxychroman-3-yl) N-propylamino] butyl) 8-azaspiro[4,5]decane-7,9 dione) and its isomers ( + ) S 20499 and (-) S 20500 are full agonists at 5-HT,, receptors. In the present study, the effects of these three compounds were investigated in t