Anxiolytic properties of (+) s 20499, a novel serotonin 5-HT1A full agonist, in the elevated plus-maze and social interaction tests
✍ Scribed by Peter F. Curle; Elisabeth Mocaer; Pierre Renard; Béatrice Guardiola
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 854 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
✦ Synopsis
Previous studies have shown that (*) S 20244 (8-(4-[N-(5-methoxychroman-3-yl) N-propylamino] butyl) 8-azaspiro[4,5]decane-7,9 dione) and its isomers ( + ) S 20499 and (-) S 20500 are full agonists at 5-HT,, receptors. In the present study, the effects of these three compounds were investigated in two animal models of anxiety, the elevated plus-maze and social interaction tests. Subcutaneous administration of (t) S 20244 (19 nmol/kg-1.9 pmol/kg), ( + ) S 20499 (470 nmol/kg) or (-) S 20500 (94-940 nmol/kg) or per 0s administration of ( + ) S 20499 (190 nmol/kg-19 pmollkg) produced anxiolytic-like effects in the elevated plus-maze while per 0s administration of (-) S 20500 was without effect. Subcutaneous administration of ( 2 ) S 20244 (19 nmol/kg-1.9 pmol/ kg) or per 0 s administration of ( + ) S 20499 (190 nmol/kg-19 pmol/kg) also produced anxiolytic-like effects in the social interaction test. With both substances, bell-shaped dose-response relationships were found. The absence of activity of (-) S 20500 when administered per os suggests that the distribution and/or absorption kinetics of the two isomers may be different. In conclusion, (5) S 20244 and ( + ) S 20499 both display anxiolytic-like activity in the elevated plus-maze and social interaction tests.