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Assessment of interactions of the antimalarial drugs chloroquine and mefloquine with NaNO2 and HgCl2 in rodents

โœ Scribed by Cesar K. Grisolia; Catarina S. Takahashi


Book ID
113194652
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
459 KB
Volume
305
Category
Article
ISSN
0027-5107

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Advances made over the last decade indicate that the mechanism of action of important antimalarial agents, such as chloroquine, involves formation of p -p complexes between drugs and ferriprotoporphyrin IX. This process is believed to block the detoxification of host haemoglobin-derived haem in the