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The role of haem in the activity of chloroquine and related antimalarial drugs

✍ Scribed by Timothy J. Egan; Helder M. Marques

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
504 KB
Volume
190-192
Category
Article
ISSN
0010-8545

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✦ Synopsis

Advances made over the last decade indicate that the mechanism of action of important antimalarial agents, such as chloroquine, involves formation of p -p complexes between drugs and ferriprotoporphyrin IX. This process is believed to block the detoxification of host haemoglobin-derived haem in the food vacuole of the parasite. Detoxification of haem occurs via conversion to a coordination polymer involving the formation of an Fe(III)-carboxylate bond between the propionate group of one ferriprotoporphyrin IX molecule and www.elsevier.com/locate/ccr

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## Abstract Despite the public health impact of human malaria, the mechanism of hemozoin inhibition by antimalarial drugs such as chloroquine (CQ) is not yet fully understood. Polarization‐resolved resonance Raman spectra of hematin and its complex with CQ were recorded under Q‐band resonance condi