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Assessing the Chromosome Copy Number in Metaphase II Oocytes by Sequential Fluorescence in Situ Hybridization

โœ Scribed by Marielle Vollmer; Friedel Wenzel; Christian DeGeyter; Hong Zhang; Wolfgang Holzgreve; Peter Miny


Book ID
111562927
Publisher
Springer US
Year
2000
Tongue
English
Weight
87 KB
Volume
17
Category
Article
ISSN
1573-7330

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DNA amplification is an important mechanism of tumor progression that allows cancer cells to up-regulate the expression of critical genes such as oncogenes and genes conferring drug resistance. Recent studies using comparative genomic hybridization (CGH) revealed increased DNA copies of 20q sequence