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A subset of gestational trophoblastic disease characterized by abnormal chromosome 8 copy number detected by fluorescence in situ hybridization

โœ Scribed by H.F.L. Mark; Alaa Afify; William Taylor; Kathleen Santoro; John C. Lathrop


Book ID
114136232
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
510 KB
Volume
99
Category
Article
ISSN
0165-4608

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DNA amplification is an important mechanism of tumor progression that allows cancer cells to up-regulate the expression of critical genes such as oncogenes and genes conferring drug resistance. Recent studies using comparative genomic hybridization (CGH) revealed increased DNA copies of 20q sequence