Binding characteristics and tumor target
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Guy W. Beresford; Gabriela Pavlinkova; Barbara J.M. Booth; Surinder K. Batra; Da
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Article
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1999
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John Wiley and Sons
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French
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Multivalency is a recognized means of increasing the functional affinity of single-chain Fvs (scFvs) for optimizing tumor uptake. A unique divalent single-chain Fv protein [sc(Fv)2], based on the variable regions of the monoclonal antibody (MAb) CC49, has been generated that differs from other dimer