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Assembly of targeting complexes driven by a single-chain antibody

โœ Scribed by Marina V Backer; Jennifer Elliot; Timur I Gaynutdinov; Joseph M Backer


Book ID
113716783
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
307 KB
Volume
289
Category
Article
ISSN
0022-1759

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Multivalency is a recognized means of increasing the functional affinity of single-chain Fvs (scFvs) for optimizing tumor uptake. A unique divalent single-chain Fv protein [sc(Fv)2], based on the variable regions of the monoclonal antibody (MAb) CC49, has been generated that differs from other dimer