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Assembly of Alzheimer-like filaments from full-length tau protein

โœ Scribed by R.A. Crowther; O.F. Olesen; M.J. Smith; R. Jakes; M. Goedert

Book ID
115930083
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
643 KB
Volume
337
Category
Article
ISSN
0014-5793

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Alzheimer's disease is characterized by the progressive deposition of two types of fibers in the affected brains, the amyloid fibers (consisting of the Abeta peptide, generating the amyloid plaques) and paired helical filaments (PHFs, made up of tau protein, forming the neurofibrillary tangles). Whi