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Rapid Assembly of Alzheimer-like Paired Helical Filaments from Microtubule-Associated Protein Tau Monitored by Fluorescence in Solution †

✍ Scribed by Friedhoff, Peter; Schneider, Anja; Mandelkow, Eva-Maria; Mandelkow, Eckhard

Book ID
118146095
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
189 KB
Volume
37
Category
Article
ISSN
0006-2960

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Rapid Assembly of Alzheimer-like Paired
Rapid Assembly of Alzheimer-like Paired Helical Filaments from Microtubule-Associated Protein Tau Monitored by Fluorescence in Solution †
✍ Friedhoff, Peter; Schneider, Anja; Mandelkow, Eva-Maria; Mandelkow, Eckhard 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 189 KB

Alzheimer's disease is characterized by the progressive deposition of two types of fibers in the affected brains, the amyloid fibers (consisting of the Abeta peptide, generating the amyloid plaques) and paired helical filaments (PHFs, made up of tau protein, forming the neurofibrillary tangles). Whi