The administration of xenogenic monoclonal antibodies (MAbs) leads in many cases to a host immune response represented by the generation of antibodies that can be directed against allotypic, isotypic, and idiotypic determinants present on the xenogeneic MAb. Anti-idiotypic antibodies (Ab2s) can be d
Assays to detect monoclonal anti-idiotypic anti-idiotypic antibodies
β Scribed by Norman Mermelstein; Grant Morahan
- Book ID
- 118900717
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 52 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0022-1759
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## ~~ Anti-idiotypic (Anti-Id) monoclonal antibodies (MoAbs) against anti-carcinoembryonic antigen (CEA) monoclonal antibody 563 (IgG1) were prepared and characterized. Five anti-Id MoAbs recognized the private idiotype of MoAb 563. ldiotype mapping suggested that MoAb 563 had at least three disti
Anti-idiotypes produced against monoclonal anti-H-2 antibodies have been used to examine idiotope sharing among a panel of anti-major histocompatibility complex (MHC) antibodies detecting the same and different specificities. Both xenogeneic anti-100-30 and anti-3-83, which did not react with predom