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Assaying poly(ADP-ribose) polymerase activity in plants by polarographic method

✍ Scribed by Ruihua Tian; Depu Chen; Yaoren Dai

Publisher: Springer
Year: 1999
Tongue: English
Weight: 356 KB
Volume: 44
Category: Article
ISSN: 1001-6538
DOI: 10.1007/bf02886346

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## Abstract Poly(ADP‐ribose)polymerase (PARP‐1), a nuclear enzyme activated by DNA strand breaks, is involved in DNA repair, aging, inflammation, and neoplastic transformation. In diabetes, reactive oxygen and nitrogen species occurring in response to hyperglycemia cause DNA damages and PARP‐1 acti