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Aryl-fused sphingolipids as novel PKC inhibitors with topical antiinflammatory activity

โœ Scribed by John J. Tegeler; Barbara S. Rauckman; R.Richard L. Hamer; Brian S. Freed; Gregory H. Merriman; Luther Hellyer; Marie Ortega-Nanos; Steven C. Bailey; Ellen S. Kurtz


Book ID
108038906
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
246 KB
Volume
5
Category
Article
ISSN
0960-894X

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The enantioselective synthesis and antii
โœ Gregory Merriman; John J. Tegeler; R.Richard L. Hamer; Barbara S. Rauckman; Bria ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 273 KB

Recently we identified three promising topically active antiinflammatory agents (2, 3, and 4) from a series of racemic aryl-sphingolipids that inhibit protein kinase C (PKC). We now wish to report the enantioselective synthesis of the aforementioned leads and their comparative biological profile. Th