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Design, syntheses, and evaluation of novel 1,1-dihalo-2,3-diphenylcyclopropanes as potential cyclooxygenase-2 (COX-2) inhibitors with analgesic-antiinflammatory activity

✍ Scribed by P.N. Praveen Rao; Amgad G. Habeeb; Edward E. Knaus


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
276 KB
Volume
55
Category
Article
ISSN
0272-4391

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A group of methyl 2-methyl-2- [2-(4-benzoyl-5-phenyl-7-halo-2-azabicyclo[4.1.0]hept-3ene)]acetates (1015), and the related acetamide derivative ( 16), that possess a variety of C-7 substituents (Br, Cl, F, H), were designed for evaluation as analgesic-antiinflammatory agents. The effect of the C-7 s