<P>The carotid body arterial chemoreceptors constitute unique sensory receptors capable of rapidly monitoring the levels of arterial blood oxygen and carbon dioxide. Whenever necessary they initiate homeostatic reflexes aimed to correct the detected deviations. Chemoreceptor cells of the carotid bod
Arterial Chemoreception
β Scribed by N. Talib, A. Verna, M. Roumy, A. Pradet (auth.), Carlos Eyzaguirre, Sal J. Fidone, Robert S. Fitzgerald, Sukhamay Lahiri, Donald M. McDonald (eds.)
- Publisher
- Springer-Verlag New York
- Year
- 1990
- Tongue
- English
- Leaves
- 483
- Edition
- 1
- Category
- Library
No coin nor oath required. For personal study only.
β¦ Synopsis
This book entitled Arterial Chemoreception is an edited compilation of the oral communications and posters presented at the IXth International SymΒ posium on Arterial Chemoreceptors held in Park City, Utah, from August 29th to September 3rd, 1988. The Symposium also saw the formal inauΒ guration and first meeting of the International Society for Arterial CheΒ moreception (ISAC). In all there were 87 presentations by 108 scientists from 18 countries. Authors making multiple presentations at Park City combined their results into single, longer papers for this volume. As a result this vol~me offers the reader 63 contributions of state-of-the-art research in this important and exciting field. Inasmuch as oxygen is the substrate sine qua non for the survival of all higher organisms, it is quite understandable that considerable interest surΒ rounds investigations into mechanisms responsible for detecting dwindling oxygen supplies in the organism. This interest has intensified as the newer techniques of cell, sub-cell, and molecular biology have become available. As detectors of insufficient oxygen in the arterial blood the arterial cheΒ moreceptors (carotid and aortic bodies) initiate many cardiopulmonary reflexes geared toward maintaining constant the delivery of oxygen to the tissues. These chemoreceptors, which also trigger secretions from the adΒ renal glands, are located near the carotid sinus and in the arch of the aorta.
β¦ Table of Contents
Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Adenine Nucleotide Content in the Rabbit Carotid Body In Vitro: Effects of Hypoxia and Metabolic Inhibitors....Pages 3-9
Role of Protein Kinase C in the Carotid Body Signal Transduction....Pages 10-13
Spectrophotometric and Fluorometric Analysis of the Rat Carotid Body Under Hypoxia....Pages 14-17
Intracellular pH of Cultured Carotid Body Cells....Pages 18-23
Immunohistochemical and In Situ Hybridization. Evidence for a Calcium-Binding Protein in the Sinus Nerve....Pages 24-30
Biophysical Studies of Cells from the Carotid Body of the Rabbit....Pages 31-43
Ionic Mechanisms of the Chemoreception Process in Type I Cells of the Carotid Body....Pages 44-57
Ionic Currents in Carotid Body Type I Cells and the Effects of Hypoxia and NaCN....Pages 58-62
Effects of Chemoexcitatory Agents on K + Currents of Isolated Type I Cells from Neonatal Rat Carotid Body....Pages 63-69
Extracellular K + as an Interneuronal Coupler in the Carotid Body....Pages 70-75
Electrical Activity of Mouse Carotid Body as Monitored by the Fluorescent Probe diS-C 3 -5: Effects of Different Agents....Pages 76-83
Front Matter....Pages 85-85
Biochemical Studies on the Release of Catecholamines from the Rat Carotid Body In Vitro....Pages 87-91
Regulation of the Release of Dopamine and Norepinephrine from Rabbit Carotid Body....Pages 92-99
Long-Term Hypoxia and Hypercapnia in the Carotid Body: A Review....Pages 100-114
Catecholamines in the Carotid Body....Pages 115-123
The Role of Acetylcholine in the Chemoreception of Hypoxia by the Carotid Body....Pages 124-130
Co-localization of Neuroactive Agents in the Carotid Body of the Cat....Pages 131-136
In Vitro Degradation of Substance P by the Carotid Body Proteases....Pages 137-142
Proenkephalin-Derived Peptides in the Carotid Body....Pages 143-147
Front Matter....Pages 149-149
Vasopressinergic Influence in the Cat Carotid Body....Pages 151-156
Front Matter....Pages 149-149
Effects of Different Stimuli and Transmitters on Glomus Cell Membranes and Intercellular Communications....Pages 157-167
Use of Selective Antagonists for Studying the Role of Putative Transmitters in Chemoreception....Pages 168-173
Endogenous Adenosine Tonically Excites Respiration Mediated by Carotid Body Chemoreceptors in the Rat....Pages 174-180
Calcium Antagonists Stimulate Carotid Body Chemoreceptors....Pages 181-185
Lack of Effect of MPTP on a Peripheral Dopaminergic Structure: The Carotid Body....Pages 186-191
The Mechanism of Action of Tachykinins in the Carotid Body....Pages 192-198
The Carotid Body and Almitrine Bismesylate....Pages 199-206
Almitrine Bismesylate and the Carotid Body: An Ultrastructural Study....Pages 207-211
Front Matter....Pages 213-213
Membrane Properties of Cat Carotid Neurons after Peripheral Regeneration....Pages 215-219
The Functional Role and Central Connections of the Carotid Body of the Rat....Pages 220-228
Tachykininergic Axons in the Guinea Pig Carotid Body: Origin, Ultrastructure, and Coexistence with Other Peptides....Pages 229-234
Hypoxia and Hypercapnia Deplete Clear Vesicles but Not Dense-Cored Vesicles in the Carotid Bodyβs Sensory Nerves....Pages 235-242
An Electronic Gating Circuit for Separation of Chemoreceptor Activity from Baroreceptor Activity....Pages 243-246
Information Content of Arterial Chemoreceptor Discharge Pattern....Pages 247-253
Flow Detection by the Carotid Body....Pages 254-259
How Real Is the Relation of Arterial Po 2 to Chemoreceptor Activity?....Pages 260-269
Effects of Hypoxia, Potassium and Other Stimuli on the Discharge of the Carotid Body....Pages 270-278
Postnatal Resetting of the Hypoxic Sensitivity of Aortic Chemoreceptors in the Lamb....Pages 279-284
Carotid Chemoreceptor Recording in the Newborn Piglet....Pages 285-289
Front Matter....Pages 291-291
Some Effects of Chronic Stimulation on the Rat Carotid Body....Pages 293-301
Front Matter....Pages 291-291
Structural Changes in the Glomus Caroticum Due to Arteriosclerosis....Pages 302-308
Calibre of Arteriovenous Blood Vessels in the Cat Carotid Body: An Assessment Using Latex Microspheres....Pages 309-315
Dopaminergic Ventilatory Inhibition in Relation to Chemoreception Sensitization in the Rat....Pages 316-322
Mechanism and Site of Effect of Chronic Erythropoietic Stimuli on Carotid Body....Pages 323-329
Carotid Sinus Receptors Participate in Glucose Homeostasis....Pages 330-336
Carotid Body Contribution to Hypoxic Ventilatory Responses in Euthermic and Hibernating Ground Squirrels....Pages 337-343
Does the Ventilatory Response to Hypoxia Measure Chemoreceptor-Mediated Drive in Humans?....Pages 344-349
Pulmonary Vagal Afferents Involved in the Hypoxic Breathing without Arterial Chemoreceptors....Pages 350-356
Plasticity of Ventilatory Chemoreflexes....Pages 357-362
Progesterone Protects against Hypoxic Ventilatory Depression in Male Rats....Pages 363-367
Possible Pitfalls in the Search for Arterial and Central Chemoreception in Respiration....Pages 368-373
Serotonin in the Human Infant Carotid Body: Normal and Pathological States....Pages 374-380
Chemostimulation during Bilateral Carotid Occlusion in the Rat....Pages 381-387
Front Matter....Pages 389-389
Sympathetic Oxygen Chemoreflex and Chemosensitive Responses....Pages 391-397
Effects of Hypoxia on Catecholamine Storage and Release in Rabbit Superior Cervical Ganglion....Pages 398-403
Involvement of Dopaminergic SIF Cells of Rat Superior Cervical Ganglion in Response to Chemoreceptor Stimuli....Pages 404-418
Neurotransmitters in Laryngeal Nerve Paraganglia: A Morphological and Biochemical Study....Pages 419-424
Hypertrophy of Abdominal Vagal Paraganglia Following Chronic Hypoxia: Compared with Carotid Body....Pages 425-431
Effects of Hypoxia on Isolated Pulmonary Neuroepithelial Body Cells In Vitro....Pages 432-437
Membrane Hyperpolarization in Hypoxic Vasorelaxation....Pages 438-445
Front Matter....Pages 389-389
Is the Cellular Thiol-Disulfide System Involved in Oxygen Sensitivity of Arterial Contraction?....Pages 446-451
Oxygen-Sensing Mechanisms in the Macrophage and Erythropoietin Production....Pages 452-456
Contribution of Renal Chemoreception to the Production of Erythropoietin....Pages 457-462
Back Matter....Pages 463-475
β¦ Subjects
Neurobiology; Zoology; Pediatrics; Pharmacology/Toxicology; Neurosciences
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