THE ARTERIAL CHEMORECEPTORS

✍ Scribed by K. RAVI, V.K. VIJAYAN (auth.), Yoshiaki Hayashida, Constancio Gonzalez, Hisatake Kondo (eds.)

• Publisher: Springer US
• Year: 2006
• Tongue: English
• Leaves: 360
• Series: Advances in experimental medicine and biology 580
• Edition: 1
• Category: Library

✦ Synopsis

The carotid body arterial chemoreceptors constitute unique sensory receptors capable of instantly monitoring the levels of arterial blood oxygen and carbon dioxide. They capture any deviations from normality and initiate bodily homeostatic reflexes aimed to correct the detected deviations. Chemoreceptor cells of the carotid body constitute ideal models to study the entire processes of O2-sensing as well as CO2-sensing.

The Arterial Chemoreceptors represents an updated review of the physiology of the carotid body chemoreceptors. More importantly, the book presents trends in the field and contains results in topics at the frontiers of future developments in O2-sensing in chemoreceptor cells.

Additionally, this volume contains data from studies carried out in other O2-sensing tissues including pulmonary vasculature and erythropoietin producing cells.

This book is a prime source of information and a guideline for every researcher in the field of arterial chemoreception. It is also an important source of information for researchers in the fields of hypoxic pulmonary vasoconstriction and pulmonary hypertension, as well as for researchers in the field of erythr

✦ Table of Contents

A TRIBUTE TO PROFESSOR AUTAR SINGH PAINTAL (1925-2004)....Pages 1-8
Immunolocalization of Tandem Pore Domain K + Channels in the Rat Carotid Body....Pages 9-14
Neuroglobin, a New Oxygen Binding Protein is Present in the Carotid Body and Increases after Chronic Intermittent Hypoxia....Pages 15-19
Hypoxia-Inducible Factor (HIF)-1α and Endothelin-1 Expression in the Rat Carotid Body during Intermittent Hypoxia....Pages 21-27
Expression of HIF-2α and HIF-3α in the Rat Carotid Body in Chronic Hypoxia....Pages 29-36
Modulation of Gene Expression in Subfamilies of TASK K + Channels by Chronic Hyperoxia Exposure in Rat Carotid Body....Pages 37-41
Postnatal Changes in Gene Expression of Subfamilies of TASK K + Channels in Rat Carotid Body....Pages 43-47
Morphological Changes in the Rat Carotid Body in Acclimatization and Deacclimatization to Hypoxia....Pages 49-54
Effect of Carbon Dioxide on the Structure of the Carotid Body A comparison between normoxic and hypoxic conditions....Pages 55-61
S-Nitrosoglutathione (SNOG) Accumulates Hypoxia Inducible Factor-1α in Main Pulmonary Artery Endothelial Cells but not in Micro Pulmonary Vessel Endothelial Cells....Pages 63-71
Changes in Antioxidant Protein SP-22 of Chipmunk Carotid Bodies during the Hibernation Season....Pages 73-78
Potential Role of Mitochondria in Hypoxia Sensing by Adrenomedullary Chromaffin Cells....Pages 79-85
Localization of Ca/Calmodulin-Dependent Protein Kinase I in the Carotid Body Chief Cells and the Ganglionic Small Intensely Fluorescent (SIF) Cells of Adult Rats....Pages 87-92
Dual Origins of the Mouse Carotid Body Revealed by Targeted Disruption of Hoxa3 and Mash1....Pages 93-97
Genetic Regulation of Chemoreceptor Development in DBA/2J and A/J Strains of Mice....Pages 99-104
Genetic Influence on Carotid Body Structure in DBA/2J and A/J Strains of Mice....Pages 105-109
The Effect of Hyperoxia on Reactive Oxygen Species (ROS) in Petrosal and Nodose Ganglion Neurons during Development (Using Organotypic Slices)....Pages 111-114
Carotid Body Volume in Three-Weeks-Old Rats Having an Episode of Neonatal Anoxia....Pages 115-119
The Effect of Development on the Pattern of A1 and A2a-Adenosine Receptor Gene and Protein Expression in Rat Peripheral Arterial Chemoreceptors....Pages 121-129
A Comparative Study of the Hypoxic Secretory Response between Neonatal Adrenal Medulla and Adult Carotid Body from the Rat....Pages 131-135
In Search of the Acute Oxygen Sensor....Pages 137-146
Does AMP-activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Pulmonary Artery Constriction?....Pages 147-154
Function of NADPH Oxidase and Signaling by Reactive Oxygen Species in Rat Carotid Body Type I Cells....Pages 155-160
Hypoxemia and Attenuated Hypoxic Ventilatory Responses in Mice Lacking Heme Oxygenase-2....Pages 161-166
Regulation of a TASK-like Potassium Channel in Rat Carotid Body Type I Cells by ATP....Pages 167-172
Accumulation of Radiolabeled N -Oleoyl-Dopamine in the Rat Carotid Body....Pages 173-178
Profiles for ATP and Adenosine Release at the Carotid Body in Response to O 2 Concentrations....Pages 179-184
Hypoxic Regulation of Ca 2+ Signalling in Astrocytes and Endothelial Cells....Pages 185-190
Does AMP-activated Protein Kinase Couple Hypoxic Inhibition of Oxidative Phosphorylation to Carotid Body Excitation?....Pages 191-196
Mitochondrial ROS Production Initiates Aβ 1-40 -Mediated Up-Regulation of L-Type Ca 2+ Channels during Chronic Hypoxia....Pages 197-201
Acute Hypoxic Regulation of Recombinant THIK-1 Stably Expressed in HEK293 Cells....Pages 203-208
Differential Expression of Oxygen Sensitivity in Voltage-Dependent K Channels in Inbred Strains of Mice....Pages 209-214
An Overview on the Homeostasis of Ca 2+ in Chemoreceptor Cells of the Rabbit and Rat Carotid Bodies....Pages 215-222
Midbrain Neurotransmitters in Acute Hypoxic Ventilatory Response....Pages 223-226
Chronic Intermittent Hypoxia Enhances Carotid Body Chemosensory Responses to Acute Hypoxia....Pages 227-232
The Cell-Vessel Architecture Model for the Central Respiratory Chemoreceptor....Pages 233-238
Loop Gain of Respiratory Control upon Reduced Activity of Carbonic Anhydrase or Na + /H + Exchange....Pages 239-244
Adrenaline Increases Carotid Body CO 2 Sensitivity: An in vivo Study....Pages 245-250
Peripheral Chemoreceptor Activity on Exercise-Induced Hyperpnea in Human....Pages 251-255
Effects of Low-Dose Methazolamide on the Control of Breathing in Cats....Pages 257-262
Stimulus Interaction between Hypoxia and Hypercapnia in the Human Peripheral Chemoreceptors....Pages 263-266
Gene Expression and Signaling Pathways by Extracellular Acidification....Pages 267-274
Hypoxic Modulation of the Cholinergic System in the Cat Carotid Glomus Cell....Pages 275-280
Are There “CO 2 Sensors” in the Lung?....Pages 281-292
Nitric Oxide in Brain Glucose Retention after Carotid Body Receptors Stimulation with Cyanide in Rats....Pages 293-300
Pulmonary Nociceptors are Potentially Connected with Neuroepithelial Bodies....Pages 301-306
Modulators of Cat Carotid Body Chemotransduction....Pages 307-311
Identification and Characterization of Hypoxia Sensitive Kvα Subunits in Pulmonary Neuroepithelial Bodies....Pages 313-318
Voltage-Dependent K Channels in Mouse Glomus Cells are Modulated by Acetylcholine....Pages 319-324
Modification of the Glutathione Redox Environment and Chemoreceptor Cell Responses....Pages 325-330
Carotid Body Transmitters Actions on Rabbit Petrosal Ganglion in Vitro ....Pages 331-337
Potassium Channels in the Central Control of Breathing....Pages 339-344
Role of Endothelin-1 on the Enhanced Carotid Body Activity Induced by Chronic Intermittent Hypoxia....Pages 345-350
Concluding Remarks....Pages 351-359

✦ Subjects

Human Physiology; Pneumology/Respiratory System; Biomedicine general; Medicine/Public Health, general