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Artefacts in evolving factor analysis-based methods for peak purity control in liquid chromatography with diode-array detection

✍ Scribed by H.R. Keller; D.L. Massart

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
604 KB
Volume
263
Category
Article
ISSN
0003-2670

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✦ Synopsis

Evolvmg factor analysis and related techmques are pronuamg methods for peak punty control m hqmd chromatography mth photodmde-array detection (DAD) Practical apphcatlon of these techmques, however, can be hnuted by Instrumental and expenmental non-ldeahtles Possible reasons Include a non-zero or slopmg basehne, the DAD scan time, cahbratlon graph non-lmearlty and heteroscedastlaty Methods are presented for contilon of the first two problems As vartous Instruments behave dtierently, It IS hkely that the relevant dfficultles depend on the Instrument used Addltlonally, one has to take mto account that mobde phase effecta, leadmg to changes m the spectra, are a potential source of artefacts The detectlon hmlt of an lmpunty as a function of chromatographlc separation, relative concentration and amount of noise was also studred for sunulated data Keywords Ltqutd chromatography, Evolvmg factor analysts, Peak purity control

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