Arteether, a new antimalarial drug: synthesis and antimalarial properties
β Scribed by Brossi, A.; Venugopalan, B.; Dominguez Gerpe, L.; Yeh, H. J. C.; Flippen-Anderson, J. L.; Buchs, P.; Luo, X. D.; Milhous, W.; Peters, W.
- Book ID
- 121271415
- Publisher
- American Chemical Society
- Year
- 1988
- Tongue
- English
- Weight
- 867 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-2623
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## Abstract The triphenylphosphine hydrobromideβcatalyzed addition of a proton from ethanol to anhydrodihydroartemisinin (5) has been employed for the synthesis of 2 and 4 Use of 1.5 equivalents of EtO^2^H or EtO^3^H yielded 11β[~3~H]βΞ²βarteether as the major product.
The stereoselective total synthesis of the antimalarial agents artemisinin-dg (1). dihydroartemisinin-d3 (2), and arteether-dg (3), incorporating ZH at C-16 (C-9 methyl) is reported.