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Synthesis of 11-[3H]-arteether, an experimental antimalarial drug

✍ Scribed by Yu-Ming Pu; Herman Ziffer

Book ID
102369288
Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
262 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The triphenylphosphine hydrobromide‐catalyzed addition of a proton from ethanol to anhydrodihydroartemisinin (5) has been employed for the synthesis of 2 and 4 Use of 1.5 equivalents of EtO^2^H or EtO^3^H yielded 11‐[~3~H]‐β‐arteether as the major product.

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