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Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer

✍ Scribed by Firozi, P. F.; Bondy, M. L.; Sahin, A. A.; Chang, P.; Lukmanji, F.; Singletary, E. S.; Hassan, M. M.; Li, D.

Book ID: 121786803
Publisher: Oxford University Press
Year: 2002
Tongue: English
Weight: 218 KB
Volume: 23
Category: Article
ISSN: 0143-3334
DOI: 10.1093/carcin/23.2.301

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## Abstract Isothiocyanates (ITCs) are nonnutrient compounds in cruciferous vegetables with anticarcinogenic properties. ITCs down‐regulate cytochrome P‐450 biotransformation enzyme levels, activate Phase II detoxifying enzymes and induce apoptosis. On the other hand, ITCs also serve as a substrate