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N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer

✍ Scribed by Kyoung-Mu Lee; Sue-Kyung Park; Sook-Un Kim; Mark A Doll; Keun-Young Yoo; Sei-Hyun Ahn; Dong-Young Noh; Ari Hirvonen; David W Hein; Daehee Kang

Book ID
117467862
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
123 KB
Volume
196
Category
Article
ISSN
0304-3835

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## Abstract Isothiocyanates (ITCs) are nonnutrient compounds in cruciferous vegetables with anticarcinogenic properties. ITCs down‐regulate cytochrome P‐450 biotransformation enzyme levels, activate Phase II detoxifying enzymes and induce apoptosis. On the other hand, ITCs also serve as a substrate