Aromatase cytochrome P450 enzyme expression in human pituitary
β Scribed by Pinar Kadioglu; Gokhan Oral; Muge Sayitoglu; Nevin Erensoy; Berna Senel; Nurperi Gazioglu; Aydin Sav; Gursel Cetin; Ugur Ozbek
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 336 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1386-341X
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The aim of this study was to test suitable culture conditions for maintaining normal cellular cytoarchitecture and inducibility of P450 enzymes in primary cultures of human hepatocytes by prototypical inducers. The selectivity and sensitivity of a sandwich culture system were determined by treating
## Objectives: The biotransformation of caffeine has been studied in vitro using human cytochrome p-450 isoenzymes (cyps) expressed in human b-lymphoblastoid cell lines, namely cyp1a1, 1a2, 2a6, 2b6, 2d6-val, 2e1 and 3a4, and microsomal epoxide hydroxylase (eh). in addition, cyp2d6-met was also stu