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Aripiprazole: A treatment for severe coprolalia in “refractory” Gilles de la Tourette syndrome

✍ Scribed by Mouna Ben Djebara; Yulia Worbe; Michael Schüpbach; Andreas Hartmann


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
56 KB
Volume
23
Category
Article
ISSN
0885-3185

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✦ Synopsis


Abstract

Coprolalia is one of the most distressing symptoms in Gilles de la Tourette syndrome. We report on a 28‐year‐old man with severe coprolalia at the forefront of symptoms, which had a dramatic impact on his social and professional life and that did not fluctuate for years. Moreover, he presented hypersensitivity to neuroleptics. The use of aripiprazole, as a last resort, induced a 75% of improvement of his symptoms with good tolerance. This suggests that aripiprazole constitutes a valuable therapeutic in coprolalia. Moreover, its biochemical class specificity makes it an alternative for patients hypersensitive to other classes of neuroleptics. © 2007 Movement Disorder Society


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