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Approaches to the synthesis of 2-sila-1-carba-cephalosporins

✍ Scribed by Sylvie Géhanne; Maria Giammaruco; Maurizio Taddei; Paola Ulivi

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
185 KB
Volume
35
Category
Article
ISSN
0040-4039

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✦ Synopsis

AbstracC A condensed B-Iactam containing a silicon atom in the B ring wets prepured starting from a~~~~t~l-(c~or~t~~)-si~~e.

The simple 6-unsubstituted structure did not show my relevant antibiotic activity, but it represents the first example of the synthesis of a molecule with a structure of a "sila-cephent".

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Stille coupling approaches to the stereo
Stille coupling approaches to the stereospecific synthesis of 7-[(E)-alkylidene]cephalosporins
✍ John D. Buynak; Venkata Ramana Doppalapudi; Mohammed Frotan; Ramon Kumar 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 213 KB

Stille coupling methodology is used to stereospecifically synthesize 7-[(E)-alkylidene]cephalosporins, potential enzyme inhibitors which are unavailable via other synthetic methodology. Two procedures are described, utilizing either a stannylalkylidene cephem which is then coupled with an organohali