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Stille coupling approaches to the stereospecific synthesis of 7-[(E)-alkylidene]cephalosporins

✍ Scribed by John D. Buynak; Venkata Ramana Doppalapudi; Mohammed Frotan; Ramon Kumar

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 213 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)02691-4

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✦ Synopsis

Stille coupling methodology is used to stereospecifically synthesize 7-[(E)-alkylidene]cephalosporins, potential enzyme inhibitors which are unavailable via other synthetic methodology. Two procedures are described, utilizing either a stannylalkylidene cephem which is then coupled with an organohalide, or a haloalkylidene cephem which is coupled with an organostannane.

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