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Approach to predict the contribution of cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage: The effect of the expression of cytochrome b 5 with recombinant P450 enzymes

✍ Scribed by Emoto, C.; Iwasaki, K.

Book ID
120333137
Publisher
Informa plc
Year
2007
Tongue
English
Weight
203 KB
Volume
37
Category
Article
ISSN
0049-8254

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The concept of relative activity factor (RAF) to extrapolate data obtained with recombinant cytochrome P450(CYP)s to human liver microsomes has been proposed. To evaluate the approach to predict the contribution of multiple CYPs using RAF, we investigated the effects of the differences in the expres