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Application of moment analysis in assessing rates of absorption for bioequivalency studies

✍ Scribed by Andre J. Jackson; Mei-Ling Chen

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
454 KB
Volume
76
Category
Article
ISSN
0022-3549

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The capacity of the statistical moments for detecting bioavailability changes in bioequivalence studies of drugs with high disposition mean residence time (MRT) is analysed. Two bioavailability trials were carried out with spironolactone in which extent and rate of absorption were modified in a cont