Application of lipases in the removal of protective groups on glycerides and glycosides
โ Scribed by M Kloosterman; E.W.J Mosmuller; H.E Schoemaker; E.M Meijer
- Book ID
- 108382990
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 244 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Pseudomonas cepacaa ltpase catalyzes the acetylatton m orgamc solvent of dihydroxyaldehydes and ketones using vmyl acetate as acyl donor The method IS completely regoselecuve and allows to obtam partrally acetylated compounds different from those obtamed by enzymic hydrolysis of polyacetoxy arylalde
The t-Butyloxycarbonyl (BOC) group on indoles and pyrroles can be removed cleanly and in high yield by simple thermolysis: no acid, no base, no solvent is required. In recent years considerable attention has been given to the problem of finding suitable protecting groups for indoles and pyrroles.2
## Abstract 2โThiopyridone (2โmercaptopyridine, **1**) was found to be a very suitable reagent for removing the __N__^ฮฑ^โoโnitrophenylsulfenyl (NPSโ) group in both conventional and solidโsupport peptide synthesis. A 3โ to 5โmolar excess of the reagent together with an equivalent amount of glacial a