Hydrogen peroxide-trichloroacetic acid is an effective reagent combination for the mild cleavage of acid-labile protective groups.
โฆ LIBER โฆ
Improved Catalyst for the Removal of Carbobenzyloxy Protective Groups
โ Scribed by Kimberly B. Humphries; Konrad Mobus; Tracy D. Dunn; Baoshu Chen
- Book ID
- 101992987
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 8 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
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## Abstract A new method is proposed for the removal of the phenylhydrazide protecting group by the action of peroxidase or laccase, the enzymes attributed to the class of oxidoreductases. The deblocking procedure is performed under mild oxidative conditions, i.e., aqueous solution and neutral or c
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