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Application of Graph Theory: Prediction of Cytosolic Phospholipase A2Inhibitory Activity of Propan-2-ones

โœ Scribed by Vipin Kumar; A. K. Madan

Book ID
106419227
Publisher
Springer
Year
2006
Tongue
English
Weight
93 KB
Volume
39
Category
Article
ISSN
0259-9791

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Synthesis and enzyme inhibitory activiti
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โœ Rut Lucas; Amalia รšbeda; Miguel Payรก; Mario Alves; Esther del Olmo; Josรฉ L. Lรณpe ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 134 KB

We have synthesised some lipidic diamines and aminoalcohols and examined their behaviour as inhibitors of secretory and cytosolic PLA2. Some structure-activity relationships considerations have been deduced. Compound 14 was a potent and selective inhibitor of cPLA2 and compound 4 showed a dual inhib