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Activation of mitogen-activated protein kinase and cytosolic phospholipase A2by hydrogen peroxide in fibroblasts

โœ Scribed by G. S. A. T. van Rossum; R. de Wit; G. Bunt; A. J. Verkleij; H. van den Bosch; J. A. Posta; J. Boonstra


Book ID
110557075
Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
123 KB
Volume
34
Category
Article
ISSN
0024-4201

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The observation that mitogen-activated protein (MAP) kinases ERK1 and ERK2 are constitutively activated in a number of oncogene-transformed cell lines has led to the hypothesis that prolonged activation of these enzymes is required for the transformation process. To investigate this question, we hav