Application of Ferrocenyl-Substituted Aziridinylmethanols (FAM) as Chiral Ligands in Enantioselective Conjugate Addition of Diethylzinc to Enones.
β Scribed by Alper Isleyen; Oezdemir Dogan
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 34 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Four phosphites obtained by linking enantiomerically pure binaphthylchlorophosphite to the two different hydroxy groups of deoxycholic acid were synthesized and used as chiral ligands in the enantioselective copper-catalyzed 1,4-addition of diethylzinc to acyclic enones. The ligands were screened fo
## Abstract New amino acidβbased modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et~2~Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high __ee__ of up to 72% were obtained using ligand (__S__)β**1e** u