Application of drug metabolism and pharmacokinetics for new drug development
โ Scribed by Yoon Gyoon Kim; Keon Wook Kang
- Book ID
- 107642572
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 151 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0253-6269
No coin nor oath required. For personal study only.
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## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t
Data from the rapid systematic study of the fate of a new drug in rats and dogs can aid the design of pharmacological and safety tests and can provide a basis for biopharmaceutic and Phase I clinical trials. Keyphrases Drug metabolism-role in drug research and development, symposium Biopharmaceutics