๐”– Bobbio Scriptorium
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New drug metabolism and pharmacokinetic package from Fisons


Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
109 KB
Volume
17
Category
Article
ISSN
0169-7439

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Comparative preclinical drug metabolism
โœ Charles B. Davis; Ramesh Bambal; Ganesh S. Moorthy; Erin Hugger; Hong Xiang; Bri ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 202 KB

The disposition of three 4-aminoquinoline leads, namely isoquine (ISO), des-ethyl isoquine (DEI) and N-tert-butyl isoquine (NTBI), were studied in a range of in vivo and in vitro assays to assist in selecting an appropriate candidate for further development. Analogous to amodiaquine (ADQ), ISO under