Application of carbonyl umpolung to prostaglandin synthesis I. Synthesis of 11-deoxy prostaglandin intermediates
✍ Scribed by Lajos Novák; Gábor Baán; Jenő Marosfalvi; Csaba Szántay
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- French
- Weight
- 207 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0040-4039
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During the last few years, much effort has been concentrated on the synthesis of 11-deoxy prostaglandins 2) , whjch aroused our interest in a convenient synthesis of 11-deoxy PGs.
In a previous paper, 2) we reported a convenient synthetic method for lldeoxy prostaglandin intermediates. In connection with this method, we are further interested in the preparation of ll-substituted prostaglandins by Wittig reaction of a-dienols with stable ylides. Now we wish to report the synt
## Smmary: A facile 1,5-migration of a t-butyldimethylsilyl group and a new cleavage reaction of t-butyldimethylsilyl ether to alcohol in prostaglandin intermediates are described.