Application of an intramolecular Heck reaction for the construction of the balanol aryl core structure
โ Scribed by Marie-Pierre Denieul; Troels Skrydstrup
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 218 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The highly functionalized aryl core structure of balanol has been synthosized employing a mgioselective intramolecular Heck reaction as the key step. This approach can potentially lead to new types of analogues of the potent PKC inhibitor.
๐ SIMILAR VOLUMES
A strategically functionalized tricyclic subunit of the manzamines was efficiently synthesized with complete stereochemical control using a combination of an intramolecular Michael reaction of a pyroglutamic acid derivative and a hydrogenation.
Highly diastereoselective construction of the chiral building blocks, with an allylic quaternary carbon stereogenic center, for the synthesis of indole alkaloids has been accomplished by employing a 1,4-chirality transfer via the intramolecular Heck reaction.