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An efficient and stereoselective construction of the core structure of the manzamines via an intramolecular Michael reaction

✍ Scribed by K.M.J. Brands; L.M. DiMichele

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
230 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A strategically functionalized tricyclic subunit of the manzamines was efficiently synthesized with complete stereochemical control using a combination of an intramolecular Michael reaction of a pyroglutamic acid derivative and a hydrogenation.

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