Application of a multi-turn time-of-flight mass spectrometer, MULTUM II, to organic compounds ionized by matrix-assisted laser desorption/ionization

✍ Scribed by Daisuke Okumura; Michisato Toyoda; Morio Ishihara; Itsuo Katakuse

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 300 KB
• Volume: 39
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/jms.575

✦ Synopsis

Abstract

The circuit shape of the ion path, or the multi‐turn, provides a solution for achieving unrestricted mass resolution from time‐of‐flight mass analyzers. The potential of a multi‐turn type mass spectrometer, the MULTUM II, with a 1.308 m circuit controlled by four toroidal electric sector fields in biological applications was examined. With matrix‐assisted laser desorption/ionization, the ion flight of 18 cycles gave a mass resolution of 10 000 for MH^+^ of protophorphyrin IX. This resolution was correlated with the flight length, and a resolution of 61 000 was achieved for MH^+^ of angiotensin I after 75 cycles or a 98.75 m total flight. The results demonstrate that the multi‐turn mass spectrometer allows not only high resolution but also very high separation of the ions of molecular species from organic compounds. Copyright © 2004 John Wiley & Sons, Ltd.