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Application of 2-chlorotrityl resin in solid phase synthesis of (Leu15)-gastrin I and unsulfated cholecystokinin octapeptide

✍ Scribed by BARLOS, KLEOMENIS ;GATOS, DIMITRIOS ;KAPOLOS, STAVROS ;POULOS, CONSTANTINE ;SCHÄFER, WOLFRAM ;WENQING, YAO


Book ID
115099279
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
623 KB
Volume
38
Category
Article
ISSN
0367-8377

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An efficient Fmoc-based solid-phase method for the synthesis of sulfated tyrosine-containing peptides is described. This synthetic approach involves two key features: (1) use of the 2-chlorotrityl resin as a solid support, and (2) a two-step cleavage/deprotection protocol. Various molecular forms of