Efficient solid-phase synthesis of sulfated tyrosine-containing peptides using 2-chlorotrityl resin: Facile synthesis of gastrin/cholecystokinin peptides

✍ Scribed by Kouki Kitagawa; Chikako Aida; Hidetoshi Fujiwara; Takeshi Yagami; Shiroh Futaki

• Book ID: 104256147
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 272 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02401-x

✦ Synopsis

An efficient Fmoc-based solid-phase method for the synthesis of sulfated tyrosine-containing peptides is described. This synthetic approach involves two key features: (1) use of the 2-chlorotrityl resin as a solid support, and (2) a two-step cleavage/deprotection protocol. Various molecular forms of gastrin-II and cholecystokinin (CCK) were prepared by this approach without difficulty.