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Applicability of nitric oxide platform to screening the cytokine-inducing activity of drugs

✍ Scribed by Zdenìk Zídek; Antonín Holý; Eva Kmoníèková


Book ID
116399036
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
64 KB
Volume
48
Category
Article
ISSN
1043-4666

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## Abstract Because the neurotoxic effects of the antifungal drug amphotericin B (AMB) closely resemble those ascribed to the highly reactive gaseous free radical nitric oxide (NO), we investigated the effect of AMB on NO production in rodent astrocytes. AMB caused a dose‐dependent increase of NO g