Involvement of Nitric Oxide on the Cytokine-Induced Growth of Glial Cell
β Scribed by M.A. Munozfernandez; M. Fresno
- Book ID
- 115573205
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 355 KB
- Volume
- 194
- Category
- Article
- ISSN
- 0006-291X
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Lipopolysaccharide (LPS) or a combination of interleukin (IL)-lp and interferon (1FN)-y cause transcriptional induction of a calcium-independent nitric oxide synthase (NOS) in astrocytes and C6 glioma cells. LPS induction of NOS in C6 cells was evidenced by a small amount of nitrite accumulation as
## Abstract The present study underlines the importance of phospholipase A~2~ (PLA~2~)β and lipoxygenase (LO)βmediated signaling processes in the regulation of inducible nitric oxide synthase (iNOS) gene expression. In glial cells, lipopolysaccharide (LPS) induced the activities of PLA~2~ (calciumβ