Endothelin enhances lipopolysaccharide-induced expression of inducible nitric oxide synthase in rat glial cells
β Scribed by Haruko Oda; Toshihiko Murayama; Yukio Sasaki; Toshikazu Okada; Yasuyuki Nomura
- Book ID
- 119414194
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 394 KB
- Volume
- 339
- Category
- Article
- ISSN
- 0014-2999
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Lipopolysaccharide (LPS) or a combination of interleukin (IL)-lp and interferon (1FN)-y cause transcriptional induction of a calcium-independent nitric oxide synthase (NOS) in astrocytes and C6 glioma cells. LPS induction of NOS in C6 cells was evidenced by a small amount of nitrite accumulation as