Human leukocyte cultures were pulse-treated with the trifunctional alkylating mutagen trenimon in a final concentration of 10(-7) M for 15--20 h after culture start, i.e., in the G1 phase of the cell cycle. At 24 h after culture start bromodeoxyuridine (BUdR) was added to the trenimon-treated cultur
✦ LIBER ✦
Apparently spontaneous chromosome damage in human leukocytes and the nature of chromatid gaps
✍ Scribed by Br�gger, Anton
- Book ID
- 104777622
- Publisher
- Springer-Verlag
- Year
- 1971
- Weight
- 988 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0018-7348
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The incidence of structural chromosome aberrations and the rate of sister chromatid exchanges (SCE) was investigated in lymphocyte cultures from a patient with typical Fanconi's anemia and his parents. The rate of SCEs was found to be normal. In experiments with the alkylating agent Trenimon the SCE