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Induction of chromosome damage and sister-chromatid exchanges in human lymphocyte cultures by the antitumour antibiotic Neocarzinostatin

✍ Scribed by Kleoniki Psaraki; Nikos A. Demopoulos

Book ID
119093127
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
361 KB
Volume
204
Category
Article
ISSN
0165-1218

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This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m