Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age
✍ Scribed by Eloise Kok; Satu Haikonen; Teemu Luoto; Heini Huhtala; Sirkka Goebeler; Hannu Haapasalo; Pekka J. Karhunen
- Book ID
- 101461674
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 189 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The effect of the apolipoprotein E (APOE) ϵ4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage
## Abstract ## Objective This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein‐E epsilon 4 allele (__APOE__ ε4), and age of disease onset in a community dwelling sample of 685 Alzheimer's disease (AD) patients spanning three ethnic g
An increased frequency of the apolipoprotein E type 4 allele (APOE-4) has previously been associated with both late-onset sporadic and late-onset familial Alzheimer disease (AD) [