Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease
✍ Scribed by van Duijn, Cornelia M.; de Knijff, Peter; Cruts, Marc; Wehnert, Anita; Havekes, Louis M.; Hofman, Albert; Broeckhoven, Christine Van
- Book ID
- 109915968
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 513 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1061-4036
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## Abstract Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and preseuilin II, cause early‐onset AD. The apolipoprotein E (APOE) gene contributes primarily to late‐onset AD. The APOE‐
## Abstract The effect of the apolipoprotein E (APOE) ϵ4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage