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Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease

✍ Scribed by Rossington, Jennifer A.; Balerdi, Matthew; Hoye, Angela J.


Book ID
124142099
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
328 KB
Volume
15
Category
Article
ISSN
0197-4580

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## Abstract Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and preseuilin II, cause early‐onset AD. The apolipoprotein E (APOE) gene contributes primarily to late‐onset AD. The APOE‐