Apolipoprotein E ε4 allele frequency is increased in Parkinson’s disease only with co-existing Alzheimer pathology
✍ Scribed by P. M. Mattila; T. Koskela; M. Röyttä; T. Lehtimäki; T. A. Pirttilä; E. Ilveskoski; P. Karhunen; J. O. Rinne
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 81 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0001-6322
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We investigated the association between apolipoprotein E (__APOE__) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both __APOE__‐ε4 allele and __APOE__ ε4/ε3 genotype are associated with PD (OR = 1.736,
It was suggested that in contrast to the E4 allele, the E2 allele of the apolipoprotein E gene (APOE"2) has a protective effect for late-onset Alzheimer's disease and early-onset Alzheimer's disease (EOAD). We studied the role of the APOE\*2 allele in the pathogenesis of EOAD in a Dutch population-b